STAT6

 Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.^[5][6]

STAT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OJ5, 4Y5W, 4Y5U
Identifiers
Aliases	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
External IDs	OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,095,408 bp[1] End 57,132,139 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.59 cM Start 127,642,986 bp[2] End 127,660,957 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • identical protein binding • sequence-specific DNA binding • protein phosphatase binding • DNA binding • GO:0001948 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • nuclear chromatin • membrane raft • cytoplasm • cytosol • nuclear membrane Biological process • regulation of transcription from RNA polymerase II promoter • T-helper 1 cell lineage commitment • regulation of cell proliferation • response to cytokine • interleukin-4-mediated signaling pathway • regulation of transcription, DNA-templated • cellular response to hydrogen peroxide • mammary gland epithelial cell proliferation • cellular response to reactive nitrogen species • positive regulation of type I interferon production • positive regulation of isotype switching to IgE isotypes • mammary gland morphogenesis • negative regulation of type 2 immune response • negative regulation of transcription from RNA polymerase II promoter • signal transduction • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • cytokine-mediated signaling pathway • positive regulation of cold-induced thermogenesis • defense response • JAK-STAT cascade • response to peptide hormone • JAK-STAT cascade involved in growth hormone signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6778	20852
Ensembl	ENSG00000166888	ENSMUSG00000002147
UniProt	P42226	P52633
RefSeq (mRNA)	NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153	NM_009284
RefSeq (protein)	NP_001171549 NP_001171550 NP_001171551 NP_001171552 NP_003144	NP_033310
Location (UCSC)	Chr 12: 57.1 – 57.13 Mb	Chr 10: 127.64 – 127.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.^[7]

InteractionsEdit

STAT6 has been shown to interact with:

• CREB-binding protein,^[8][9]
• EP300,^[8]
• IRF4,^[10]
• NFKB1,^[11]
• Nuclear receptor coactivator 1,^[9][12] and
• SND1.^[13]

PathologyEdit

• Gene fusion
  • Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.^[14]
• Amplification
  • STAT6 is amplified in a subset of dedifferentiated liposarcoma.^[15]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.