STAT2

 Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.^[5][6] It is a member of the STAT protein family.

STAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KA4
Identifiers
Aliases	STAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3
External IDs	OMIM: 600556 MGI: 103039 HomoloGene: 3952 GeneCards: STAT2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,341,597 bp[1] End 56,360,167 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 76.5 cM Start 128,270,559 bp[2] End 128,292,849 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948 protein binding • identical protein binding • ubiquitin-like protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signal transducer activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component • cell membrane • nucleoplasm • cell nucleus • cytoplasm • cytosol Biological process • JAK-STAT cascade • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • GO:0022415 viral process • signal transduction • regulation of protein phosphorylation • defense response to virus • regulation of mitochondrial fission • type I interferon signaling pathway • cytokine-mediated signaling pathway • defense response • regulation of cell proliferation • response to peptide hormone • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6773	20847
Ensembl	ENSG00000170581	ENSMUSG00000040033
UniProt	P52630	Q9WVL2
RefSeq (mRNA)	NM_005419 NM_198332	NM_019963
RefSeq (protein)	NP_005410 NP_938146	n/a
Location (UCSC)	Chr 12: 56.34 – 56.36 Mb	Chr 10: 128.27 – 128.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.^[6]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.